There are two competing goals for the surgical treatment of prostate cancer - reduction of margin rates and preservation of neurovascular tissue. Master surgeons have achieved a fine balance between these two goals. This symposium is aimed at highlighting these innovations in the context of robotic-assisted prostatectomy by incorporating important and often critical points from the experience of those who have mastered open radical prostatectomy. Participants will benefit from presentations of professional stereoscopic (3D) clinical videos and an interactive conference format. The focus will be on the anatomic and scientific foundations of nerve sparing, continence preservation; strategies to minimize margins; innovations that assist surgeons in making better intraoperative decisions; future directions of robotic surgery, and the development of innovative protocols, including the use of PDE5 inhibitors, growth factors, and neuroprotective agents.